Straight up no. That's my personal take others may feel different.
These are 'psychological' levels which are only expected by traders to act as a turning point. I wouldn't even open a 'touch trade' on parity.
You look at the chart and use the price action to find your s/r levels, then you use these horizontal levels to base your trading decisions on.
Go back through your charts, and have a look at these big round numbers - you will find that price can chop through them and make a lot of noise around them. But if I get a nice price action signal off a big round number that is actually acting as support or resistance, then yeah Ill go for it. But the big round numbers never comes into my decision making process.